Grand Saline, Texas is a city in Van Zandt County located in East Texas. Grand Saline the third-largest city in Van Zandt County with a population of 3,292 as of 2024.

Located roughly 75 miles (120 km) east of Dallas on Hwy 80, and 35 miles (56 km) northwest of Tyler, the two nearest metropolitan areas, Grand Saline is considered part of the greater Tyler/Longview area.

The town derives its name from the large salt deposits located southeast of the city, the majority of which are owned by Morton Salt.